Hashim Amla and Jacques Kallis led South Africa past 150 runs in the third and final one-dayer against India in Ahmedabad.
Hashim Amla hit a patient half-century after Yusuf Pathan drew the first blood for India by dismissing Loots Bosman.
Ravindra Jadeja was well-placed at long-off to take an easy catch to pack off SA’s first wicket. Bosman hit a quick-fire half-century.
Amla and Bosman opened the batting after South Africa won the toss and elected to bat first against India.
The duo did some early hitting as the visitors crossed the 50-run mark quickly.
With the series as well as the number two spot in ICC rankings in their grasp, India are aiming for a rare clean sweep at Motera.
Meanwhile, South Africa have nothing but pride to play for in the third and final cricket one-dayer in Ahmedabad on Saturday.
The home team will be without more than half a dozen key players in the dead rubber, some missing from action from the start of the series and others – including champion batsman Sachin Tendulkar – skipping the tie.
India: M S Dhoni (Capt.), M Vijay, Dinesh Karthik, Virat Kohli, Suresh Raina, Rohit Sharma, Yusuf Pathan, Ravindra Jadeja, Sudeep Tyagi, S Sreesanth, R Ashwin, Amit Mishra, Abhimanyu Mithun and Ashish Nehra.
South Africa: Jacques Kallis (Capt.), Loots Bosman, Johan Botha, Hashim Amla, Mark Boucher, A B de Villiers, J P Duminy, Herschelle Gibbs, Charl Langeveldt, Albie Morkel, Morne Morkel, Wayne Parnell, Alviro Petersen, Dale Steyn, Lonwabo Tsotsobe and Roelof van der Merwe.